N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide
KS176
CAS: 1253452-78-6
Molecular Formula: C22H19N3O5
N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide - Names and Identifiers
N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide - Physico-chemical Properties
| Molecular Formula | C22H19N3O5 |
| Molar Mass | 405.4 |
| Density | 1.401±0.06 g/cm3(Predicted) |
| Boling Point | 510.1±50.0 °C(Predicted) |
| Solubility | DMSO : ≥ 35 mg/mL (86.33 mM) |
| Appearance | powder |
| Color | white to beige |
| pKa | 11.60±0.70(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Use | KS176 is a selective and highly active breast cancer drug resistance protein multidrug transport channel (BCRP) inhibitor (IC50 values in Pheo A and Hoechst tests are 0.59 and 1.39 μM respectively). No inhibitory activity on P-gp and MRP1. |
| Target | BKCa-channel; BCRP(Pheo A) |
N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide - Risk and Safety
| WGK Germany | 3 |
N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide - Reference
| Reference Show more | 1. Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem. 2010 Sep 3;5(9):1498-505. |
N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.467 ml | 12.333 ml | 24.667 ml |
| 5 mM | 0.493 ml | 2.467 ml | 4.933 ml |
| 10 mM | 0.247 ml | 1.233 ml | 2.467 ml |
| 5 mM | 0.049 ml | 0.247 ml | 0.493 ml |
Last Update：2024-01-02 23:10:35
N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide - Reference Information
| biological activity | KS176 (compound 9) is an effective and selective inhibitor of breast cancer resistance protein (BCRP, ABCG2) multidrug transporter. IC50 values in Hoechst 33342 analysis and Pheo A analysis are 1.39 μM and 0.59 μM respectively. |
| target | TargetValue BCRP (in Pheo A say) 0.59 μM BCRP (in Hoechst 33342 say) 1.39 μM |
| Target | Value |
| BCRP (in Pheo A assay) | 0.59 μM |
| BCRP (in Hoechst 33342 assay) | 1.39 μM |
Last Update：2024-04-10 22:29:15
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Product Name: KS176 Visit Supplier Webpage Request for quotationCAS: 1253452-78-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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